The win gives the Chiefs (5-0) their best start since 2003 and makes them the first team in NFL history to win their first five games a season after winning two or fewer.
Kansas City struck first with their special teams as Marcus Cooper recovered a muffed punt in the end zone for a touchdown early in the first quarter.
Ryan Succop added the first two of his four field goals to give the Chiefs a 13-0 lead at halftime.
The Titans (3-2) then scored 17 unanswered to grab their only lead of the game. Chris Johnson to a pitch from Ryan Fitzpatrick, starting in place of an injure Jake Locker, 49 yards to score less than three minutes into the second half.
Fitzpatrick ran a nine-yard keepr into the end zone at the start of the fourth quarter to give Tennessee the lead.
Alex Smith completed 20 of 39 passes for 245 yards while tossing an interception.
Jamaal Charles accounted for the offense's lone score, a one-yard plunge as part of a 22-carry, 108-yard performance.
Donnie Avery caught three balls for 91 yards before leaving the game with a shoulder injury.
The Chiefs now head back home for a three-game stretch, beginning next Sunday with their first divisional game with Oakland.