Bob Sutton's unit sacked Terrelle Pryor 10 times and hauled in three interceptions, the last returned for a touchdown by Husain Abdullah, to help beat the Raiders 24-7 on Sunday.
The win gives the Chiefs their first 6-0 start since 2003 on the same day Arrowhead Stadium entered the Guinness Book of World Records as the loudest outdoor stadium in the world.
The ten sacks are one shy of the team's single-game mark and the most since they racked up 10 against Oakland in 1998. Tamba Hali led the game with 3 1/2, Derrick Johnson recorded a pair, and five others had at least a hand in one.
The defense's three interceptions, grabbed by Abdullah, Marcus Cooper, and Quintin Demps, were in the absence of Brandon Flowers, who missed the game after injuring his knee in practice this week.
Prior and the Raiders (2-4) took advantage of that in the second quarter as the quarterback connected with Denarius Moore for a 39-yard touchdown pass to open the scoring.
Kansas City responded with just over a minute before halftime with Jamaal Charles, who plowed in from seven yards out to tie it 7-7. It was the first of his two scores on the day, giving him a touchdown and over 100 yards from scrimmage in every game this season. He picked up 78 yards on 22 carries while also leading the team in receiving with 50 yards on five catches.
Alex Smith completed 14 of 31 passes for 128 yards while rushing four times for 49 yards.