Running back Henry Josey -- in his first game back since tearing his left ACL, MCL and patellar tendon nearly two years ago -- rushed for 113 yards and a touchdown on 13 carries. Russell Hansbrough picked up 104 yards and two touchdowns on the ground as the Tigers rushed for 358 yards as a team on the Racers.
The Tigers (1-0) didn't start fast, though.
Murray State's Walter Powell hit Maikhai Miller for a 17 yard touchdown just 2:25 into the first quarter, and after getting down by six later in the frame, went back up 14-13 on another touchdown pass.
Mizzou hit the gas from that point on in the game outscoring the Racers 45-0 in the final three quarters.
Hansbrough had Missouri's first two scores, the first on a three-yard touchdown run, the next from 51 yards out.
In the second quarter, Mizzou took the lead for good on a James Franklin 22-yard touchdown pass to Jimmie Hunt. Marcus Murphy scored on a rush from four yards out, and capped off the half with a field goal from Andrew Baggett. The Tigers led 30-14 at the break.
Franklin hooked up with Darius White and L'Damian Washington for scores early in the third quarter before Josey broke out.
The junior from Angleton, Texas broke off a 68-yard touchdown run to cap off a 21-point third quarter.
Franklin finished 26-38 for 318 yards and three touchdowns.
Redshirt freshman Maty Mauk even made an appearance going 2-3 for 18 yards.
Mizzou's one setback came in the kicking game. Baggett was 1-2 on field goals and 7-8 on extra points.
The Tigers host Toledo next Saturday.