The bust came after officers were called to investigate a hotline call at a home on the 1700 block of Third Street.
Authorities say that investigation led officers to another home on the 600 block of Missouri Avenue where they found the meth lab.
Six children were taken into state custody for their protection.
The Chillicothe Police Department says 29-year-old Michael Holtzclaw, 27-year-old Josh Holtzclaw, 27-year-old Kelly Holtzclaw and 26-year-old Sarah Holtzclaw were all arrested for manufacturing methamphetamine, possession of methamphetamine, endangering the welfare of a child and possession of methamphetamine paraphernalia.
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