The wreck shut down the northbound lanes of I-29 north of Platte City Monday night.
Two semi trucks and at least three vehicles were involved.
Troopers say Jerry R. Wofford, 65, was taken to Heartland Regional Medical Center where he is being treated for serious injuries and Robert J. Sanko, 45, was taken to North Kansas City Hospital where he is being treated for moderate injuries.
Robert A. Dixon, 42, Debra L. Nichols, 55, and Willie E. McIntosh, 53, were all treated for minor injuries. Richard R. Fox, 43, was involved in the accident but not injured.
According to troopers, Sanko, Dixon, Nichols, McIntosh and Fox were all wearing their safety belts, while it is unknown if Wofford was wearing his.
Troopers are still investigating the cause of the crash.
Stay with KQ2 for updates on this developing story.