The first in a series of blasts to bring down the Amelia Earhart Bridge in Atchsion will take place at 9:00 a.m.
Two more blasts will happen in the following days to completely demolish the 75-year-old bridge.
The demolition has faced several delays.
The old Amelia Earhart Bridge was built in 1938.
A new $60 million four lane bridge opened to traffic in June.