The accident happened on Highway 59 just north of 238th Street around 3:00 p.m.
The crash killed Joel Wilburn, 25, of Atchison and Richard Jacobs, 77, of Topeka.
The Kansas Highway Patrol says Jacobs was driving northbound in a Ford Explorer when he crossed the center line and hit Wilburn's Pontiac Grand Prix head-on killing both drivers.
Troopers say the Jacobs was not wearing a seat belt.
Investigators are still trying to determine what caused Jacobs to cross the center line.
Highway 59 was shut down for more than three hours as the Kansas Highway Patrol worked to clear the scene.