And Romeo Crennel's Chiefs will be looking for a second straight victory against AFC west foe San Diego.
The Chiefs beat New Orleans in overtime last week thanks to six Ryan Succop field goals.
Chief running back Jamaal Charles carried the ball 33 times and says he can handle the load.
"A lot of people didn't think I could carry the ball that many times. Everybody always thought 16 or 20 was the most for me. But I went out there and did whatever the coaches wanted me to do, I showed up," Charles says.
Reporter: Do you have 33 in you this week?
"Whatever the coaches want me to carry the ball," says Charles. "I have to do something to help the team get a win. I'm just trying to help my team the best way I can."
Sunday's game from Arrowhead starts at noon. You can watch it on CBS