"Two lane highways are a little more dangerous than your interstate system because there is no barrier between you and the oncoming traffic," said Lt. Scott Meyer with the Missouri State Highway Patrol.
He said drivers need to take extra caution when driving these roads because of curves in the roadway, little shoulders and little room for error.
"You need to slow down," he said. "You need to take your time."
Casey Easter lives near 59 Highway, on the Missouri side, farther northeast of where Tuesday's accident happened.
He drives a stretch of the road every day.
"There's like a very narrow bridge that I cross and that concerns me almost every time I go across it cause if someone goes off on that line you have no leeway, you're just going to smack in the center wall," he said.
Meyer said while the recent accidents have occured on two lane highways in rural areas, the Highway Patrol sees plenty of accidents on the interstate system as well.
"We have them on the interstate, and we have them on two lane highways," he said. "People need to slow down. We need to pay attention to what we're doing out here behind the wheel of a car."
He said no matter where drivers are, taking some simple safety precautions, like wearing your seatbelt and paying attention can help prevent tragedies.