Gov. Jay Nixon signed legislation Thursday that requires any student who attends a public university and lives on campus to be vaccinated against the virus.
There are some exemptions to the law, including students who have signed letters from doctors for a medical condition or a religious exemption.
Most universities in the state already suggest students get the vaccine because the deadly virus can spread quickly in crowded places.
"It stops students from saying 'yeah I know about it but I don't really care'," said Northwest Missouri State University Assistant Director of Wellness Evan Rand." "It forces you to say if there's really no hard reason not to get this I'm going to be protected, I'm going to be healthy and I'm going to keep this life threatening disease away."
The new law takes effect next July.