They are in town for an alternative spring break that allows them to give back to communities through projects like Habitat for Humanity.
This week, they traded in the college life for hard hats and hammers.
"Instead of going and doing some crazy fun think like go to Daytona Beach or Panama City, they're coming to St. Joe to do good community work," said Melissa Koch, Habitat for Humanity.
The group traveled to St. Joseph from Salem State University in Massachusetts.
"It's an amazing feeling to help another community other than your own. I find it really important," said KiKi McKenna, Salem State University senior.
McKenna and others are pitching in this week to finish a Habitat for Humanity home on South 17th Street.
"There's a couple that know some from what they've done in this past. They've been on other habitat trips," said Paul Davidson, construction supervisor. "But, most of them, it's the first time."
The Collegiate Challenge has been around for years, connecting thousands of college students with projects throughout the country.
"I'm so incredibly proud of them. We have a lot of interest in these kinds of trips - more than we could meet the need to send students out," said Bruce Perry, Salem State University.
The group includes volunteers who chose St. Joseph because of the hospitality during past visits.
"They took such good care of us and we had such a great experience that we wanted that for the new students that are coming," added McKenna.
Twenty-one students will work alongside volunteers and other staff to finish as much as they can before leaving on Saturday.