"We're looking for speed mainly," said Missouri State Highway Patrol Sgt. Jacob Angle. "People are in a hurry to get to their destinations and we want to encourage people to slow down."
Troopers are conducting what they call a holiday accident reduction effort.
They'll not only have extra eyes out on the roads looking for speeders but also in the air.
"We've got air craft up doing speed operations from the air," said Sgt. Angle. "It's visibility. We want people to see that trooper out there and maybe they'll look down at their speedometer and slow down."
J'aime River and her son are traveling from Tennessee to Utah.
They say the drive through the Show-Me-State, so far, has been good.
"We haven't hit any traffic," said River. "There's been some construction zones but mostly we drove a lot last night. Today's been fine."
No matter where you plan to travel this weekend, authorities want to make sure you make it to your destination.
"As always, we just encourage everyone to watch their distracted driving, put those cell phones down and always wear a seat belt," Sgt. Angle advised.
MoDOT has suspended all construction in the state until Tuesday.
Six people were killed and 63 others were injured in traffic crashes during Memorial Day weekend in Missouri last year.
According to AAA, more than 36 million Americans will travel 50 miles or more from home this weekend.
Of those traveling for Memorial Day, 31.8 million will go by automobile.