The President's response follows days of outrage after the shooting death of an unarmed teenager, Michael Brown.
"I've already tasked the Department of Justice and the FBI to investigate the death of Michael Brown," said President Obama.
President Obama called for peace and calm during the investigation.
"Now's the time for healing. Now's the time for peace and calm on the streets of Ferguson," he said.
Missouri Governor Jay Nixon also spoke in Ferguson Thursday morning.
"We must make sure that justice prevails," he said. "Without fear or favor, we must find the truth."
Gov. Nixon said it's important to seek the truth, but to do so in a peaceful manner.
"We need that safety. But, we also need to allow folks that want to express their energy in an appropriate way to have the absolute right to do that," said Gov. Nixon.
Missouri Senator Claire McCaskill says the police response in Ferguson has become part of the problem rather than part of the solution.
"There's three points. I think the police response needs to be demilitarized. I think the police response has become part of the problem. Second, people have a right to protest. Third, practice patience. A lot of independent eyes on this investigation," she said.
McCaskill spoke during a meeting of clergy and community members outside St. Louis.
Meanwhile, tensions remain high in Ferguson where dozens of protesters have been arrested and police have used tear gas on crowds.