Capt. Erik Holland with the Platte County Sheriff's Office said his office received a call around 8:30 p.m. Saturday night of an accident on 45 north of Weston.
According to Holland, a Chevy Sedan collided with a farm implement being pulled behind a pickup near Stanton Road. The sedan rolled several times.
The driver of the sedan was taken by helicopter to a Kansas City area hospital with serious injuries. Holland said the driver was in stable condition.
The highway will remain closed in both directions as crews work to clear the scene of the crash.