But Wainwright made one more in the seventh, giving up a go-ahead ground-rule double to Stephen Drew and an RBI single to Jacoby Ellsbury that helped lift Boston to a 3-2 win over the Cardinals. The victory puts St. Louis in a 3-2 hole in with the series shifting back to Boston on Wednesday.
Wainwright rebounded from a rough start in Game 1 at Fenway Park, striking out 10 batters while allowing just one walk over seven innings.
Lester was even sharper, though, allowing four hits and no walks while striking out seven over 7 2/3 frames. The only run he allowed came in the fourth inning when Matt Holliday smacked a solo shot to center, tying the game at 1-1.
Koji Uehara worked the final 1 1/3 innings for his second save of the series.
David Ortiz also continued his scorching series, registering another three hits to move to 11-for-15 with two homers and six RBI in the Fall Classic.
Michael Wacha is scheduled to take the mound against John Lackey for Game 6 on Wednesday.