The Red Sox hit around rookie Michael Wacha -- a pitcher trying to become the only player with five wins in the postseason -- and closed the Fall Classic in six games.
Shane Victorino drove in four runs -- including a three-RBI double in the third to break a scoreless tie -- on two hits in his first game back after missing two games with lower back tightness.
Boston designated hitter David Ortiz was named World Series most valuable player going 11-16 at the plate in the series with two home runs, six RBI and eight walks.
Wacha had just a 1.00 ERA through 27 postseason innings entering game six Wednesday night, but was shelled for six earned runs in 3 2/3 innings.
John Lackey, on the other hand, pitched well for the Red Sox allowing one earned run on nine hits in 6 2/3 innings with five strikeouts.
Lackey and the Boston relievers limited St. Louis, as the Cardinals left nine runners on the bases.
This is Boston's third World Series victory in the last ten years, and second over St. Louis. The Red Sox swept the Cardinals in four games in 2004.