Delays and the eventual closure of I-35 from Route 6 to U.S. Highway 36 were caused by pigs loose on the roadway after a tractor trailer turned on its side.
MoDOT officials also said crews had to spill diesel fuel off the interstate from the truck overturning.
A Missouri State Highway Patrol crash report says 60-year-old John Sciortino of Albany, Mo., was taken to Cameron Regional Medical Center by ambulance with serious injuries.
The crash report stated Sciortino was southbound on the interstate around 7:30 Wednesday morning when he lost control of his pickup, crossed the median and hit a 2004 Kenworth.
The Kenworth, driven by 48-year-old Steven Marlatt of Ridgeway, Mo., then crossed the median and overturned across the southbound lanes.
The Kenworth was hauling pigs that scattered across the median and onto the roadway, further delaying cleanup efforts.