The study from "Trust for America's Health" found many states lack effective strategies to curb the problem.
The study evaluated each state on several strategies that have shown promise in fighting against prescription drug abuse.
Those include prescription drug monitoring programs and laws that require special education for medical providers who prescribe painkillers.
The study found that many states simply don't have these programs in place.
Missouri has the seventh highest drug overdose mortality rate in the United States, according to the report.
The report ranked Kansas as the eighth lowest for its drug overdose mortality rate.
Click here to view the full report.