Krista Meeks, 17, of Riverside, is charged with first degree involuntary manslaughter after she allegedly sold the synthetic LSD to two freshmen boys in Platte County.
"We have not heard of another case that involves this specific type of synthetic drug," Platte County Sherriff Mark Owen said.
Authorities said Meeks told them she sold the drugs to the boys even though she noticed they looked very young. She allegedly told investigators "if they are going to buy it, then they should know what they are taking."
The teens were both taken to Children's Mercy Hospital after taking the drug in early October of 2013.
The 15-year-old later died. His autopsy revealed "intoxication from a synthetic compound found in the drug" caused his death.
The investigation led police to a home in Kansas City, Kan. where they seized 1,800 units of the drug.
Jamell Montgomery, 18, of Kansas City, allegedly connected the boys to Meeks so they could buy the drug. He faces a charge of distribution of an imitation controlled substance.
Meeks also faces the distribution charge and another for possessing marijuana and drug paraphernalia. She is being held on a $25,000 bond.
"It's an awful thing and as a father myself, I can only imagine," Platte County Prosecutor Eric Zahnd said.