The Platte County teenager died over the weekend.
Deputies say they responded to a home on Friday after the teen took a substance known as "acid."
He was taken to the hospital where he later died.
Deputies arrested 17-year-old Krista Meeks and 18-year-old Jamell Montgomery.
They're now charged with distributing the substance.
The victim was a student at Park Hill High School.
His name has not been released.