It happened shortly after 10 a.m. near Mitchell Avenue.
A witness at the scene, Pat Hinchey, said he saw the woman's Chevy pick-up hit a pole, then the vehicle went airborne.
"It was just one vehicle involved that I saw," he said.
Police say the driver was taken away by ambulance to Heartland hospital and later transferred to a different location.
She was not wearing a seat belt at the time of the crash. Officer Wayne Byrom said the truck overturned at least once. He said the driver appeared to have head, spinal and possibly hip and pelvic injuries.
"We really encourage people to wear their seat belt and take it slow, especially as the weather changes this weekend," said Byrom.
Police redirected southbound traffic near the site of the accident while crews worked to clear debris and investigate the cause of the crash.
The woman's name has not been released.